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Coagulation Abnormalities and Clinical Complications in Children With SARS-CoV-2: A Systematic Review of 48,322 Patients

Department of Surgery, Duke University Department of Surgery Division of Pediatric Hematology-Oncology Department of Pediatrics Division of Pediatric Surgery, Duke University Medical Center Duke University School of Medicine Duke University Medical Center Library and Archives, Durham, NC.

Journal of pediatric hematology/oncology. 2021
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PICO Summary

Population

Paediatric patients with SARS-CoV-2 (126 studies, n= 48,332).

Intervention

Systematic review to evaluate coagulation abnormalities and clinical complications.

Comparison

Outcome

Thirty-four (27%) studies reported thrombotic complications in 504 patients. Thirty-one (25%) studies reported bleeding complications in 410 patients. Ninety-eight (78%) studies reported abnormal laboratory values in 6,580 patients. Finally, 56 (44%) studies reported anticoagulant and/or antiplatelet usage in 3,124 patients.
Abstract
Given the limited information on the coagulation abnormalities of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in pediatric patients, we designed a systematic review to evaluate this topic. A comprehensive literature search was conducted for "SARS-CoV-2," "coagulopathy," and "pediatrics." Two authors independently screened the articles that the search returned for bleeding, thrombosis, anticoagulant and/or antiplatelet usage, and abnormal laboratory markers in pediatric patients with SARS-CoV-2, and the authors then extracted the relevant data. One hundred twenty-six publications were included. Thirty-four (27%) studies reported thrombotic complications in 504 patients. Thirty-one (25%) studies reported bleeding complications in 410 patients. Ninety-eight (78%) studies reported abnormal laboratory values in 6580 patients. Finally, 56 (44%) studies reported anticoagulant and/or antiplatelet usage in 3124 patients. The variety of laboratory abnormalities and coagulation complications associated with SARS-CoV-2 presented in this review highlights the complexity and variability of the disease presentation in infants and children.
Study details
Study Design : Systematic Review
Language : eng
Additional Material : Letter in: ‘Journal of Pediatric Hematology/Oncology’, (2022), PMID: 36036523, DOI: <a href="http://dx.doi.org/10.1097/MPH.0000000000002513">http://dx.doi.org/10.1097/MPH.0000000000002513</a>
Credits : Bibliographic data from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine