Evaluation of solvent/detergent-treated plasma in patients with a prolonged prothrombin time

Hematology Section, Department of Medicine, Valhalla, N.Y., USA.

Vox Sanguinis. 2000;79((3):):161-7.
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OBJECTIVES To compare the laboratory and clinical outcome of patients who received solvent/detergent-treated plasma (SDP) and fresh-frozen plasma (FFP). METHODS A randomized, double-blinded study to assess the ability of SDP and FFP to reduce a prolonged prothrombin time (PT) to ≤15 s in patients with acquired coagulation deficits. RESULTS 45 patients (22 SDP vs. 23 FFP) were treated with 71 infusions. There were no significant differences in mean dose of plasma infused (7.8 ml/kg for SDP vs. 8.0 ml/kg for FFP, p = 0.46), percentage of patients who corrected their PT to ≤15 s (32% for SDP vs. 26% for FFP, p = 0.67), or percentage of patients whose bleeding ceased (27% for SDP vs. 22% for FFP). CONCLUSION No clinical or statistically significant differences were observed after infusion with SDP or FFP in patients with acquired coagulation deficits. Copyright 2000 S. Karger AG, Basel
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Language : English
Credits : Bibliographic data from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine