Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Canada., Pediatric Hematology and Oncology, Johann Wolfgang Goethe University, Frankfurt, Germany., Leeds General Infirmary, Leeds Teaching Hospitals, NHS Trust, Leeds, UK; Centre for Reviews and Dissemination, University of York, York, UK., Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Canada., Program in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Canada., Program in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Canada; Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Canada., Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Canada; Program in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Canada. Electronic address: lillian.sung@sickkids.ca.