McMaster University, Hamilton, 1280 Main Street West, Hamilton, ON L8S 4L8, Canada; Biogen, 14 Cambridge Center, Cambridge, MA, USA; Sobi , SE-112 76 Stockholm, Sweden; University of Copenhagen, Norregade 10, 1165 Copenhagen, Denmark; Analysis Group, 111 Huntington Avenue, Fourteenth Floor , Boston, MA, 02119, USA.