Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, the Department of Intensive Care, Alfred Hospital, the Department of Haematology, Monash Health, the Department of Intensive Care, Austin Hospital, the University of Melbourne, Research and Development, Australian Red Cross Blood Service, and the Department of Intensive Care, Western Health - all in Melbourne, VIC, Australia; Irish Critical Care Clinical Trials Network, University College Dublin Clinical Research Centre at St. Vincent's University Hospital, Dublin; the Departement de Medecine Intensive Reanimation, Brest University Hospital, Brest, France; the Department of Anesthesiology and the Division of Intensive Care, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki; and the Medical Research Institute of New Zealand and the Department of Critical Care Medicine, Auckland City Hospital, Auckland, New Zealand