Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada; McMaster Centre for Transfusion Research, McMaster University, Hamilton, ON, Canada. McMaster Centre for Transfusion Research, McMaster University, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada; Center for Innovation, Canadian Blood Services, Ottawa, ON, Canada. Electronic address: heddlen@mcmaster.ca. Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada. McMaster Centre for Transfusion Research, McMaster University, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada; Center for Innovation, Canadian Blood Services, Ottawa, ON, Canada. Department of Medicine, McMaster University, Hamilton, ON, Canada; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada. Department of Medicine, McMaster University, Hamilton, ON, Canada; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Population Health Research Institute, Hamilton, ON, Canada. Meir Medical Centre, Kfar Saba, Israel. Section of Transfusion Medicine and Hematopoietic Progenitor Cell Laboratory, Cleveland Clinic, Cleveland, OH, USA. Department of Outcomes Research, Cleveland Clinic, Cleveland, OH, USA. Flinders Medical Centre, Adelaide, SA, Australia. Department of Outcomes Research, Cleveland Clinic, Cleveland, OH, USA. Meir Medical Centre, Kfar Saba, Israel. Flinders Medical Centre, Adelaide, SA, Australia. McMaster Centre for Transfusion Research, McMaster University, Hamilton, ON, Canada; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada. McMaster Centre for Transfusion Research, McMaster University, Hamilton, ON, Canada; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada; Medical Office, Canadian Blood Services, Ottawa, ON, Canada. McMaster Centre for Transfusion Research, McMaster University, Hamilton, ON, Canada. McMaster Centre for Transfusion Research, McMaster University, Hamilton, ON, Canada. Department of Medicine, McMaster University, Hamilton, ON, Canada; Population Health Research Institute, Hamilton, ON, Canada.