Back to Search Results

Efficacy and safety of topical tranexamic acid in knee arthroplasty

Cirugia Ortopedica y Traumatologia, Hospital Universitario Fundacion Alcorcon, Alcorcon, Madrid, Espana. Electronic address: alhualda@hotmail.com. Cirugia Ortopedica y Traumatologia, Hospital Universitario Fundacion Alcorcon, Alcorcon, Madrid, Espana. Cirugia Ortopedica y Traumatologia, Hospital Universitario Fundacion Alcorcon, Alcorcon, Madrid, Espana. Cirugia Ortopedica y Traumatologia, Hospital Universitario Fundacion Alcorcon, Alcorcon, Madrid, Espana.

Medicina Clinica. 2018;151((11):):431-434
Full text from:

Other resources

Abstract
INTRODUCTION AND OBJECTIVE Tranexamic acid (TXA) is commonly used to control postoperative blood loss in total knee arthroplasty. In order to avoid adverse effects associated with intravenous administration, topical use has been proposed as an alternative. Our aim was to evaluate the efficacy and safety of topical TXA in total knee arthroplasty. MATERIAL AND METHODS A total of 90 patients scheduled for unilateral total knee arthroplasty were included in a prospective randomised study. All surgeries were performed under spinal anaesthesia, tourniquet and the same postoperative protocol. Patients were allocated to one of the 3 groups according to the application of TXA: group A (n=30) 1g of topical TXA; group B (n=30) 1g of TXA intravenous and in group C or the control group (n=30) no drug was administrated. Parameters related to blood loss and drain outputs were compared between the 3 groups. RESULTS The results revealed that post-operative decrease in haemoglobin level was significantly lower in group A (1.95g/dL) than group B (2.25g/dL) and group C (2.96g/dL), P<.01. Total postoperative blood loss was lower in group A (195mL) than group B (466mL) and group C (718mL), P<.01. There was no significant difference in complications and allogenic blood transfusion rate between the 3 groups. CONCLUSIONS According to the results, topical application of 1g TXA significantly reduced blood loss in patients undergoing total knee arthroplasty more than intravenous or no administration of TXA.
Study details
Language : English, Spanish
Credits : Bibliographic data from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine