A quick scoping review of efficacy, safety, economic, and health-related quality-of-life outcomes of short- and long-acting erythropoiesis-stimulating agents in the treatment of chemotherapy-induced anemia and chronic kidney disease anemia

Arantes, Luiz H Jr. Pfizer Inc, New York, NY, USA. Electronic address: Luiz.Arantes@pfizer.com. Crawford, Jeffrey. Department of Hematology-Oncology, Duke University Medical Center, Durham, NC, USA. Gascon, Pere. Hospital Clinic de Barcelona, University of Barcelona, Barcelona, Spain. Latymer, Mark. Pfizer Ltd, Sandwich, UK. Launay-Vacher, Vincent. Service ICAR Pitie-Salpetriere University Hospital, Paris, France. Rolland, Catherine. Envision Pharma Group, London, UK. Scotte, Florian. Medical Oncology and Supportive Care Department, Hospital Foch, Suresnes, France. Wish, Jay. Indiana University Health, Indianapolis, IN, USA.

Critical Reviews in Oncology-Hematology.. 2018;129:79-90.
Erythropoiesis-stimulating agents (ESAs) are man-made forms of erythropoietin used in the treatment of anemia. This quick-scoping review of systematic literature reviews (SLRs) was conducted to define the clinical, economic, and health-related quality of life (HRQoL) outcomes for short-acting and long-acting ESAs in patients with chronic kidney disease-induced anemia (CKD-IA) and patients with chemotherapy-induced anemia (CIA). Embase, Medline, and the Cochrane Database of Systematic Reviews were searched from their establishment until October 2017. SLRs related to the use of short-acting and long-acting ESAs in the treatment of CIA and CKD-IA were included. Forty-eight studies met the inclusion criteria. The evidence suggests little difference in efficacy, HRQoL, and safety outcomes among ESA types. Cost-effectiveness and market price are likely to become determining factors driving the choice of agent. Comparative studies and costing models accounting for the utilization of biosimilars are needed to establish which ESAs are more cost-effective.Copyright © 2018. Published by Elsevier B.V.
Study details
Study Design : Systematic Review
Language : English
Credits : Bibliographic data from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine