Division of Hematology and Thromboembolism, Department of Medicine, and. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada. Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL. Coagulation Unit, Division of Haematology, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden. Division of Clinical Pharmacology and Toxicology, Department of Medicine, McMaster University, Hamilton, ON, Canada. Department of Pharmacotherapy, University of Utah College of Pharmacy, Salt Lake City, UT; and. Division of General Internal Medicine, Department of Medicine, McMaster University, Hamilton, ON, Canada.