Platelet transfusion thresholds in premature neonates (PlaNeT-2 trial)

Estcourt, L J. NHS Blood and Transplant, National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford, UK. Estcourt, L J. Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

Transfusion Medicine. 2019;29(1):20-22
Abstract
<span class="section-head">CLINICAL QUESTION</span> Does transfusing platelets to preterm infants (< 34 weeks) at a higher platelet count threshold count (< 50 x 109 /L) reduce the risk of major bleeding or death compared to only transfusing platelets when the platelet count drops below 25 x 109 /L.<span class="section-head"> EVIDENCE FROM TRIAL</span> Preterm infants with a low platelet count who were transfused platelets at the higher platelet count threshold had a higher risk of dying or having a major bleed than those who were not. The reasons why this occurred are currently unclear. Copyright &#xa9; 2019 British Blood Transfusion Society.
Study details
Language : English
Credits : Bibliographic data from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine