Department of Biomedical and Molecular Sciences, School of Medicine, Queen's University, Kingston, Canada. School of Baccalaureate Nursing, St Lawrence College, Kingston, Canada. School of Medicine, Queen's University, Kingston, Canada. Katharine Dormandy Haemophilia and Thrombosis Centre and Department of Obstetrics and Gynaecology, The Royal Free NHS Foundation hospital, London, UK. University College, London, UK.