Effect of plateletpheresis on hematocrit, hemoglobin and erythrocyte count: Meta-analysis 1980-2018

Microbiologo y Bioanalisista. MSc Microbiologia y Bioanalisis. Grupo de investigacion Salud y Sostenibilidad, Escuela de Microbiologia, Universidad de Antioquia, Medellin Colombia, Banco de Sangre Universidad de Antioquia, Medellin, Colombia. Bacteriologa y laboratorista Clinica, MSc Microbiologia y Bioanalisis, Universidad de Antioquia, Hospital General de Medellin Luz Castro de Gutierrez, Medellin, Colombia. Microbiologo y Bioanalisista, MSc Epidemiologia, MSc Economia aplicada, PhD (candidato) Salud Publica, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellin, Colombia. jaiberthcardona@gmail.com.

Scientific reports. 2019;9(1):19770
The effects of platelet donation by apheresis on different parameters of the erythrogram are still unclear. The objective was to meta-analyze the effect of plateletpheresis on hematocrit, hemoglobin, and erythrocyte count, with a systematic review with random effects meta-analysis of the mean difference. The PRISMA guidelines were considered, as well as 133 search strategies on four different databases. Reproducibility was guaranteed and methodological quality was evaluated. Heterogeneity was evaluated with Galbraith and DerSimonian-Laird's, publication bias with a funnel plot and a Begg's test, sensitivity analysis and a cumulative meta-analysis were also conducted. Eighteen (18) articles were included, 17 evaluated the effects on hematocrit in 2,564 donors; 13 on hemoglobin in 1,640 donors; and 4 on red blood cell count in 243 donors. A decrease of 2.26% (CI95% = 2.11-2.41) was observed in hematocrit, of 0.80 g/dL (CI95% = 0.75-0.86) in hemoglobin and -0.21 x 10(12)/L (CI95% = -0.13; -0.29) in red blood cell count. Plateletpheresis has a negative effect on the erythrogram parameters, explained by blood loss in the kits used for the procedure and cell lysis. Such evidence is relevant to secure the efficiency and safety of the procedure, improve selection processes or determine the number of donations that can be performed without affecting donors' health.
Study details
Study Design : Systematic Review
Language : eng
Credits : Bibliographic data from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine