Departement de Cardiologie, CHU Timone, Marseille F-13385, France; Aix Marseille Univ, Inserm, Inra, C2VN, Marseille, France; Aix-Marseille Universite, Faculte de Medecine, F-13385 Marseille, France. Hopital Bichat, Assistance Publique-Hopitaux de Paris, Paris, France; Universite Paris-Diderot, Departement Hospitalo-Universitaire FIRE, Sorbonne-Paris Cite, Paris, France; FACT (French Alliance for Cardiovascular clinical Trials), an F-CRIN network,l: NHLI, Royal Brompton Hospital, Imperial College, London, United Kingdom. Heart Center Freiburg University, Cardiology and Angiology I, Faculty of Medicine, Freiburg, Germany. Newark Beth Israel Medical Center, Rutgers-New Jersey Medical School, Newark, New Jersey, USA. Departement de Cardiologie, CHU Timone, Marseille F-13385, France. McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada. Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Department of Cardiology, Duke Clinical Research Institute, Durham, NC, USA. Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. Latvian Centre of Cardiology, Pauls Stradins Clinical University Hospital, University of Latvia, Pilsonu Street 13, Riga, Latvia. Electrophysiology Unit, Department of Cardiology, Fondazione Cardiocentro Ticino, via Tesserete 48, 6900 Lugano, Switzerland. Hopital Bichat, Assistance Publique-Hopitaux de Paris, Paris, France; Universite Paris-Diderot, Departement Hospitalo-Universitaire FIRE, Sorbonne-Paris Cite, Paris, France; FACT (French Alliance for Cardiovascular clinical Trials), an F-CRIN network,l: NHLI, Royal Brompton Hospital, Imperial College, London, United Kingdom. Electronic address: gabriel.steg@aphp.fr