University of East Anglia (UEA), Norwich Research Park, Norwich NR4 7TJ, United Kingdom; Norfolk and Norwich University Hospital, Colney Lane, Norwich NR4 7UY, United Kingdom. Electronic address: J.Reinhold@uea.ac.uk. University of Cambridge, The Old Schools, Trinity Ln, Cambridge CB2 1TN, United Kingdom; Royal Papworth Hospital, Papworth Road, Cambridge Biomedical Campus, Cambridge CB2 0AY, United Kingdom. University of East Anglia (UEA), Norwich Research Park, Norwich NR4 7TJ, United Kingdom; Norfolk and Norwich University Hospital, Colney Lane, Norwich NR4 7UY, United Kingdom.