Department of Medical Pharmacology, Faculty of Medicine, Inonu University, Malatya, Turkey. Department of Hematology, Faculty of Medicine, Inonu University, Malatya, Turkey.
International journal of clinical practice. 2020;:e13967
Sickle cell anemia (SCA) is an autosomal recessive disease caused by a mutation in the gene that codes the β-globin chain of hemoglobin. The abnormal hemoglobin (hemoglobin S) can polymerize when deoxygenated, changing the physical properties of the red cells (which deform to a sickle shape, hence the name) and damages cell membranes.(1) Sickle cell anemia can lead to a
variety of signs and symptoms namely vaso-occlusive attacks (presenting as pain, tissue hypoxia, necrosis, and organ damage), acute chest syndrome, hemolytic crisis, and primary and secondary stroke.