1 Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia. 2 Division of Intensive Care, Department of Anaesthesiology, Intensive Care and Pain Medicine, Helsinki University Hospital and University of Helsinki, Finland. 3 Department of Emergency Care and Services, Helsinki University Hospital and University of Helsinki, Finland. 4 Centre for Integrated Critical Care, The University of Melbourne, Melbourne, VIC, Australia. 5 Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia. 6 Department of Physiology and Pharmacology, Section of Anaesthesia and Intensive Care, Karolinska Institutet, Stockholm, Sweden. 7 Department of Intensive Care, Western Health, Melbourne, VIC, Australia. 8 Department of Intensive Care, Royal Melbourne Hospital, Melbourne, VIC, Australia. 9 School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland. 10 St Vincent's University Hospital, Dublin, Ireland. 11 Department of Intensive Care and Hyperbaric Medicine, The Alfred, Melbourne, VIC, Australia. 12 Department of Anaesthesia and Intensive Care, Hôpitaux universitaires Paris Sud (HUPS), Université Paris Sud XI, Paris, France. 13 Departement d'anesthésie-réanimation, Hopital de la Cavale Blanche, Boulevard Tanguy Prigent, CHRU de Brest, Univeristé de Bretagne Occidental, Brest, France. 14 King Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. 15 Department of Critical Care Medicine, Auckland City Hospital, Auckland, New Zealand. 16 Department of Anesthesiology and Intensive Care, Kuopio University Hospital & University of Eastern Finland, Kuopio, Finland. 17 Department of Intensive Care, Austin Health, Melbourne, VIC, Australia.