Ferric carboxymaltose for the treatment of iron-deficient heart failure patients: a systematic review and meta-analysis

Department of Medicine, University of Mississippi Medical Centre, Jackson, MS, USA. Department of Medicine, DOW University of Health Sciences, Karachi, Pakistan. Department of Cardiology and Pneumology, University of Göttingen Medical Center, Göttingen, Germany. German Center for Cardiovascular Research (DZHK), partner site Göttingen, Göttingen, Germany. BCRT-Berlin Institute of Health Center for Regenerative Therapies, Charite, Universitätsmedizin Berlin, Berlin, Germany. Department of Cardiology (Virchow Klinikum), Charité- Universitätsmedizin Berlin, German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany. Monash University, Australia. University of Warwick, Coventry, UK.

ESC heart failure. 2020;7(6):3392-3400
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Abstract
AIMS: Intravenous ferric carboxymaltose (FCM) has been shown to improve functional capacity and quality of life in iron deficient heart failure patients. However, FCM's effect on hospitalizations and mortality remains unclear as previous randomized controlled trials (RCTs) and their meta-analyses have been underpowered to detect significant differences. We sought to conduct an updated meta-analysis using recently published RCT data. METHODS... TS Online databases were searched from inception until November 2020 for RCTs evaluating the effects of FCM on clinical outcomes in iron-deficient heart failure patients. Outcomes of interest included heart failure hospitalizations, all-cause mortality, and cardiovascular mortality. Meta-analysis was performed using a fixed-effect model and estimates were reported as odds ratios (ORs), hazard ratios, or rate ratios (RRs) along with corresponding 95% confidence intervals (CIs). A total of 1947 patients (n = 1062 in the FCM group; n = 885 in the placebo group) were included. FCM, compared with placebo, significantly reduced the risk of the composite endpoint of time to first heart failure hospitalization or cardiovascular death (hazard ratio = 0.76; 95% CI = 0.63-0.90; I(2) = 55%). FCM also significantly reduced the risk of recurrent heart failure hospitalizations (RR = 0.68; 95% CI = 0.54-0.85; I(2) = 71%) and recurrent cardiovascular hospitalizations (RR = 0.71; 95% CI = 0.59-0.86; I(2) = 56%). However, FCM had no significant effect on the risk of all-cause (OR = 0.97; 95% CI = 0.73-1.28; I(2) = 0%) or cardiovascular mortality (OR = 0.93; 95% CI = 0.69-1.27; I(2) = 0%). CONCLUSIONS Ferric carboxymaltose reduces heart failure hospitalizations and cardiovascular hospitalizations with no beneficial effect on all-cause and cardiovascular mortality in iron-deficient heart failure patients. These findings reinforce the role of FCM as a therapeutic option in heart failure patients.
Study details
Study Design : Systematic Review
Language : eng
Credits : Bibliographic data from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine