Effect of different platelet rich fibrin matrices for ridge preservation in multiple tooth extractions: a split-mouth randomized controlled clinical trial

KU Leuven, Department of Oral Health Sciences, Section of Periodontology and Oral Microbiology &, University Hospitals Leuven Dentistry, Leuven, Belgium. KU Leuven, Department of Imaging and Pathology, OmfsImpath Research Group, Department of Oral and Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium. Karolinska Institutet, Department of Dental Medicine, Stockholm, Sweden.

Journal of clinical periodontology. 2021
AIM: To evaluate dimensional changes in the alveolar ridge and bone structure after tooth extraction when L-PRF or A-PRF+ were used in comparison to unassisted socket healing. MATERIALS AND METHODS Twenty patients in need of at least three tooth extractions in the aesthetic zone were included. L-PRF, A-PRF+ or control were randomly assigned, leaving one empty socket/edentulous site between conditions. CBCT scans were obtained immediately after tooth extraction and after 3 months of healing. Horizontal and vertical dimensional changes of the ridge and socket fill were calculated. Histological and micro-CT analysis of bone biopsies were used to evaluate post-surgical bone structural healing. RESULTS Mean horizontal and vertical changes at 1-mm below the crest (buccal and palatal side) were similar for the three sites (p>0.05). For the socket fill, L-PRF (85.2%) and A-PRF+ (83.8%) showed superior values than the control (67.9%). The histological and radiological analysis reported more newly formed bone for the PRF groups, without any significant differences between both. CONCLUSIONS PRF matrices failed to reduce the dimensional changes after multiple tooth extractions in the premaxilla. After 3-months healing, both PRF matrices showed radiographically a significant superiority for the socket fill. Histologically, they seemed to accelerate new bone formation.
Study details
Language : eng
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