Efficacy of topical application of autologous platelet-rich plasma in adult tonsillectomy patients: a randomised control study

J Laryngol Otol. 2021 Jun;135(6):539-544 doi: 10.1017/S0022215121000402.
Abstract
OBJECTIVE:

Tonsillectomy is a painful surgery performed in cases of recurrent tonsillitis. Application of platelet-rich plasma to diminish the pain and morbidity post-tonsillectomy is gaining importance. This study evaluated post-operative pain and morbidity after autologous platelet-rich plasma application on the tonsil beds during tonsillectomy.

METHOD:

Participants were randomised into group 1 (n = 28, peri-operative platelet-rich plasma intervention) and group 2 (n = 28, control). Post-tonsillectomy, patients were assessed (day 0, 1, 2, 3, 7 and 14) for pain, healing and time taken to return to normal activity. Data were analysed by independent t-test and chi-square test with p ≤ 0.05 as the significance level.

RESULTS:

A significant decrease in the mean pain score up to day 7 (p < 0.05) and tonsillar fossae healing on days 2 and 3 (p < 0.05) post-tonsillectomy was noted. The majority of the patients returned to their routine activities after a week post-tonsillectomy.

CONCLUSION:

Platelet-rich plasma application was effective in accentuating healing and reducing post-tonsillectomy pain and morbidity.

Metadata
KEYWORDS: Pain; Palatine Tonsil; Platelet-Rich Plasma; Tonsillectomy; Visual Analog Scale
MESH HEADINGS: Administration, Topical; Adolescent; Adult; Female; Humans; Male; Middle Aged; Pain, Postoperative; Platelet-Rich Plasma; Postoperative Care; Postoperative Complications; Single-Blind Method; Tonsillectomy; Tonsillitis; Young Adult
Study Details
Study Design: Randomised Controlled Trial
Language: eng
Credits: Bibliographic data from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine