Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, UK. NIHR Nottingham Biomedical Research Centre and the University of Nottingham, Nottingham, UK. Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria. The Royal Wolverhampton NHS Trust, Wolverhampton, UK. Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, UK. matthew.brookes@nhs.net. The Royal Wolverhampton NHS Trust, Wolverhampton, UK. matthew.brookes@nhs.net.