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Targeted Albumin Therapy Does Not Improve Short-Term Outcome in Hyponatremic Patients Hospitalized With Complications of Cirrhosis: Data From the ATTIRE Trial

Institute of Liver and Digestive Health, University College London, United Kingdom. Comprehensive Clinical Trials Unit, University College London, United Kingdom. Glasgow Royal Infirmary, Glasgow, United Kingdom. Barts and the London School of Medicine and Dentistry Queen Mary University of London. National Institute for Health Research Nottingham Biomedical Research Centre at Nottingham University Hospitals NHS Trust and the University of Nottingham, Queens Medical Centre, Nottingham. Mid and South Essex NHS Foundation Trust, Basildon & Thurrock University Hospitals NHS Foundation Trust, Honorary Consultant in Gastroenterology, Hepatology and Hepatobiliary Medicine, The Royal Free Hospital, Honorary Senior Lecturer, University College London, Honorary Senior Clinical Lecturer, Kings College London.

The American journal of gastroenterology. 2021
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Abstract
INTRODUCTION Patients with decompensated cirrhosis and hyponatremia have a poor prognosis. We investigated Albumin to Prevent Infection in Chronic Liver Failure trial data to determine whether targeted albumin infusions improved outcome in patients with hyponatremia at baseline. METHODS We examined the interaction between targeted albumin and standard care for the composite primary end point, stratifying by baseline sodium ≥ and <130 mmol/L. RESULTS Randomization to albumin was associated with a significant increase in sodium; however, there was no interaction between sodium category and treatment for the trial primary end point. DISCUSSION Targeted intravenous albumin infusions increased serum sodium level in hospitalized hyponatremic patients with cirrhosis, but this did not improve outcome.
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Language : eng
Credits : Bibliographic data from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine