Discipline of Paediatrics, Trinity College, the University of Dublin. Trinity Translational Medicine Institute (TTMI), Trinity College Dublin & Trinity Research in Childhood Centre (TRiCC). Paediatrics, Children's Hospital Ireland (CHI) at Tallaght, Dublin. Paediatrics, Coombe Women and Infants University Hospital. Trinity Biomedical Sciences Institute (TTMI), TCD. Neonatology, CHI at Crumlin, Dublin, Ireland.
AIM: Pulmonary haemorrhage (PH) is an acute catastrophic event with low incidence yet high mortality among neonates. We aimed to systematically review the management of PH. METHODS A search was carried out of the PubMed, Embase and Cochrane databases according to the PRISMA guidelines. Data was extracted on study design and size, patient demographics, primary and adjunctive treatment methods, and
treatment outcomes. RESULTS Sixteen studies with 385 newborn infants were included and were significantly heterogenous regarding treatment methods. Primary treatments included surfactant, High Frequency Oscillatory Ventilation (HFOV), epinephrine, coagulopathy management, intermittent positive pressure ventilation, cocaine, and tolazoline. Adjunctive treatment methods included blood products, HFOV, increased positive end expiratory pressure, vitamin K, surfactant, adrenaline, vasopressors, and inotropes. All five studies using surfactant as primary treatment were effective in improving oxygenation index measures and preventing recurrence of PH, and three studies found no association between surfactant and death or long-term disability. Ventilatory support, epinephrine, management of coagulopathy and tolazoline were all found to be effective primary treatments for PH. CONCLUSION There are several effective methods of managing PH in neonates. Further understanding of the aetiology of PH and ongoing research will allow future prevention and improvements in management of PH.