Department of Anesthesia, St. Michael's Hospital, Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada. Division of Hematology, Departments of Medicine, Laboratory Medicine and Pathobiology, Institute of Health Policy Management and Evaluation, University of Toronto, Mount Sinai Hospital, Toronto, Ontario, Canada. Department of Anesthesia and Critical Care, Hospital Universitari and Politecnic La Fe, Valencia, Spain. Clinic for Anaesthesia, Intermediate Care, Prehospital Emergency Medicine and Pain Therapy, University Hospital Basel, Switzerland. Department of Anesthesia, Austin Hospital, Melbourne, Victoria, Australia. Department of Anesthesiology & Department of Medicine, Critical Care Division, Centre hospitalier de l'Université de Montréal, Montreal, QC, Canada. Carrefour de l'innovation et santé des populations, Centre de recherche du CHUM, Montreal, QC, Canada. Department of Anaesthesia and Perioperative Medicine, Groote Schuur Hospital and Faculty of Health Sciences, University of Cape Town, South Africa. Division of Adult Cardiothoracic Surgery, Department of Surgery, University of California San Francisco and San Francisco VA Medical Center, San Francisco, California, USA. Department of Surgery, The University of Melbourne and The Royal Melbourne Hospital, Royal Melbourne Hospital, Parkville, Victoria, Australia. Department of Surgery, The University of Melbourne, Melbourne, Victoria, Australia. Outcomes Research Consortium, The Cleveland Clinic, Cleveland, Ohio, USA. Department of Cardiac Anaesthesia and Intensive Care Medicine, Emergency Institute for Cardiovascular Diseases, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. Department of Cardiac Anaesthesia, Epic Hospital, Ahmedabad, Gujarat, India. Department of Anesthesiology and Perioperative Medicine, Kingston General Hospital, Kingston, Ontario, Canada. Fundación Cardioinfantil-Instituto de Cardiología, Bogota; Universidad Autónoma de Bucaramanga, Bucaramanga, Columbia. Department of Anesthesiology, Perioperative and Pain Medicine, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Department of Anesthesia, St. Michael's Hospital, Li Ka Shing Knowledge Institute, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada. Applied Health Research Centre, Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada. Department of Anesthesia, St. Michael's Hospital, Li Ka Shing Knowledge Institute, Department of Physiology, University of Toronto, Toronto, Ontario, Canada. Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Institute of Health Policy, Management and Evaluation University of Toronto; ICES, Toronto, Ontario, Canada. Division of Cardiac Surgery, St. Michael's Hospital, Li Ka Shing Knowledge Institute, Department of Surgery, Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada. Department of Anesthesia, St. Michael's Hospital, Li Ka Shing Knowledge Institute, Institute of Medical Sciences, Department of Physiology, University of Toronto, Toronto, Ontario, Canada.