FORM, Frankfurt Oral Regenerative Medicine, Clinic for Maxillofacial and Plastic Surgery, Goethe University, Theodor-Stern-Kai 7, 60596, Frankfurt/ Main, Germany. Department of Oral Surgery and Implantology, Carolinum, Goethe University, Frankfurt, Germany. Department of Orthodontics, University of Düsseldorf, 40225, Düsseldorf, Germany. FORM, Frankfurt Oral Regenerative Medicine, Clinic for Maxillofacial and Plastic Surgery, Goethe University, Theodor-Stern-Kai 7, 60596, Frankfurt/ Main, Germany. Shahram.Ghanaati@kgu.de.