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A Systematic Review and Meta-Analysis on Racial Disparities in Deep Venous Thrombosis and Pulmonary Embolism Events in COVID-19 Hospitalized Patients

Department of Critical Care, Mayo Clinic, Jacksonville, FL. Division of Vascular and Endovascular Surgery, Mayo Clinic, Jacksonville, FL. Electronic address: erben.young@mayo.edu. Department of Critical Care, Mayo Clinic, Jacksonville, FL; Department of Transplant, Mayo Clinic, Jacksonville, FL. Division of Vascular and Endovascular Surgery, Mayo Clinic, Jacksonville, FL. Department of Political Science and Economics, Rowan University, Glassboro, NJ. Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN. Mayo Clinic Libraries, Mayo Clinic, Jacksonville, FL. Department of General Surgery, Mayo Clinic, Jacksonville, FL. Department of Neurology, Mayo Clinic, Jacksonville, FL.

Journal of vascular surgery. Venous and lymphatic disorders. 2022
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Abstract
OBJECTIVE COVID-19 is associated with an increased risk of venous thromboembolic events (VTE). Recent studies have characterized racial disparities in the incidence of VTE. The aim of our study was to present a systematic review and meta-analysis to assess the association between race and VTE in hospitalized COVID-19 patients. METHODS We performed a systematic literature review to evaluate the number of deep vein thrombosis (DVT) and pulmonary embolism (PE) events reported by racial groups in COVID-19 hospitalized patients. For qualitative analysis, independent reviewers extracted data from eligible studies, and we utilized the Newcastle-Ottawa Scale to assess the quality of design and content for accurate interpretation. For the quantitative analysis, we pooled the ORs with Der Simonian and Laird random effects models. RESULTS The qualitative analysis included 11 studies, and the meta-analysis had six of them. All studies were observational, retrospective cohort studies, except for one retrospective case-control study. Six studies were eligible for the meta-analysis due to high interstudy heterogeneity; thus, variable reports of racial groups reduced the cohort to Black/African American and White patients (n = 9723) in the analysis. The estimated proportion for DVT/PE for Black/African American and Whites was 0.07 (95% CI [0.00, 0.10]) and 0.04 (95% CI [0.00, 0.07]), respectively. The p value of 0.13 suggest non-significant difference in VTE rates between Black/African American and White patients. CONCLUSION In our study, the proportion of DVT/PE events between Black/African American and White COVID-19 patients were comparable. Future COVID-19 studies should include systematic racial group reporting to identify disparities in the setting of thromboembolic events.
Study details
Study Design : Systematic Review
Language : eng
Credits : Bibliographic data from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine