Outcomes and Implementation Research Unit, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada. Department of Internal Medicine, St. Mary's Hospital, Saint Louis, Missouri, USA. The State University of New York at Buffalo Department of Internal Medicine, Buffalo, New York, USA. Lincoln Medical and Mental Health Center, The Bronx, New York, USA. Department of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA. Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. Department of Hematology/Oncology, University of Kansas Medical Center, Kansas City, Kansas, USA. Hemophilia and Thrombosis Center, Hematology Department, S. Bortolo Hospital, Vicenza, Italy. The Royal Free NHS Foundation Hospital and Institute for Women's Health, University College London, London, UK. Centre for Haematology, Imperial College London, London, UK. Division of Pediatric Hematology Oncology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan, USA. Department of Hematology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. Middle Village, New York, USA. Mary M. Gooley Hemophilia Treatment Center, University of Rochester, Rochester, New York, USA. Department of Medicine, Queen's University, Kingston, Ontario, Canada. Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Department of Pediatrics, Medical College of Wisconsin, Versiti Blood Research Institute, Milwaukee, Wisconsin, USA. Division of Nephrology and Hypertension, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.