Department of Clinical, Internal Medicine, Anesthesiologic and Cardiovascular Sciences Sapienza University of Rome, Rome. lorenzo.loffredo@uniroma1.it. Mediterranea Cardiocentro, Napoli. Cardiovascular Sciences Department, Agostino Gemelli Foundation Polyclinic IRCCS, Rome, Italy; Catholic University of The Sacred Heart, Rome. Department of Clinical, Internal Medicine, Anesthesiologic and Cardiovascular Sciences Sapienza University of Rome, Rome. Department of Clinical, Internal Medicine, Anesthesiologic and Cardiovascular Sciences Sapienza University of Rome, Rome, Italy; Mediterranea Cardiocentro, Napoli. francesco.violi@uniroma1.it.