Multisystemic Inflammatory Syndrome in Neonates: A Systematic Review

Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Neonatology, King Saud University Medical City, Riyadh, Saudi Arabia. Neonatal Consultant, SIDRA Medicine, Ar-Rayyan, Qatar. Pediatric Infectious Disease, Pediatric Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. Pediatric Rheumatology, Pediatric Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada. Department of Pediatrics, Toronto University, Toronto, Ontario, Canada. Maternal-Infant Care Research Center, Mount Sinai Hospital, Toronto, Ontario, Canada.

Neonatology. 2022;:1-13
INTRODUCTION Multisystem inflammatory syndrome in neonates (MIS-N) related to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has increasingly been reported worldwide amid the spread of the SARS-CoV-2 pandemic. METHODS We searched PubMed, EMBASE, and CINAHL and preprint servers ( and using a specified strategy integrating Medical Subject Headings terms and keywords until October 20, 2021. Our aim was to systematically review demographic profiles, clinical features, laboratory parameters, complications, treatments, and outcomes of neonates with MIS-N. Studies were selected when fulfilling the inclusion criteria. Articles were included if they fulfilled the World Health Organization (WHO), Centers for Disease Control (CDC) definitions of MIS-C, or our proposed definition. RESULTS Sixteen reports of MIS-N including 47 neonates meeting MIS-N criteria were identified. Presentation included cardiovascular compromise (77%), respiratory involvement (55%), and fever in (36%). Eighty-three percent of patients received steroids, and 76% received immunoglobulin. Respiratory support was provided to 60% of patients and inotropes to 45% of patients. Five (11%) neonates died. CONCLUSION The common presentation of MIS-N included cardiorespiratory compromise with the possibility of high mortality. Neonates with MIS-N related to SARS-CoV-2 may be at higher risk of adverse outcomes.
Study details
Study Design : Systematic Review
Language : eng
Credits : Bibliographic data from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine