Comparison of transfusion reactions in children and adults: A systematic review and meta-analysis
There are no international standards or normalizations for diagnosing and treating complications from blood transfusions. We comprehensively compared the incidence of adverse blood transfusions in children and adults.
METHODS:Available literature on blood transfusion adverse reactions in children and adults prior to November 27, 2021 was collected from several electronic databases. This meta-analysis was performed using Revman 5.2 and Stata 15.1.
RESULTS:The incidence of transfusion reactions is higher in children than in adults. Children transfused with red blood cells and platelets exhibited a higher incidence of transfusion reaction than that of adults. Moreover, the incidence of allergic and febrile non-hemolytic transfusion reactions was significantly higher in children than in adults. The incidence of some rare transfusion reactions was also significantly higher in children than in adults.
CONCLUSION:The incidence of transfusion reactions in children and adults is varied. Guidelines for children are necessary.
KEYWORDS: | adult; adverse reaction; blood transfusion; pediatrics; transfusion reaction |
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MESH HEADINGS: | Adult; Blood Transfusion; Child; Erythrocytes; Humans; Hypersensitivity; Incidence; Transfusion Reaction |
Study Design: | Systematic Review |
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Language: | eng |
Credits: | Bibliographic data from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine |