Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada. Department of Anesthesia and Pain Management, Sinai Health System, Women's College Hospital, University Health Network, Toronto, Ontario, Canada. Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada. Interdepartmental Division of Critical Care, Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Institute for Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada. Department of Pathology and Molecular Medicine, Kingston Health Sciences Centre and Queen's University, Kingston, Ontario, Canada. University of Toronto Quality in Utilization, Education and Safety in Transfusion Research Program, Toronto, Ontario, Canada. Precision Diagnostics and Therapeutics Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.