1Department of Advanced Biomedical Sciences, University Federico II of Naples, Naples, Italy. Cardiology Department, Alto Vicentino Hospital, Santorso, Italy; 3Cardiovascular Research Institute, Mater Private Hospital, Royal College of Surgeons in Ireland, Dublin, Ireland; ISAResearch Center, Deutsches Herzzentrum München, Technisches Universität München, Munich, Germany. Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada. University of British Columbia, Vancouver, Canada. Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada. University Hospital and Faculty of Medicine Pilsen, Charles University, Czech Republic. Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy. The Duke Clinical Research Institute, Durham, NC. Department of Cardiology, Isala Heart Center, Zwolle, the Netherlands. Quebec Heart and Lung Institute, Quebec City, Quebec, Canada. Department of Advanced Biomedical Sciences, University Federico II of Naples, Naples, Italy. Department of Cardiology, University Hospital of Bern, Bern, Switzerland. Applied Health Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital, and Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Department of Cardiology, University Hospital of Bern, Bern, Switzerland; Division of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland.