Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada. Toronto Health Economics and Technology Assessment (THETA) Collaborative, University Health Network, Toronto, Ontario, Canada. Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada. Biostatistics Research Unit, University Health Network, Toronto, Ontario, Canada. Department of Pathology and Molecular Medicine, Kingston Health Sciences Centre and Queen's University, Kingston, Ontario, Canada. Department of Anesthesia and Pain Management, Sinai Health System, Women's College Hospital, University Health Network, Toronto, Ontario, Canada. Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada. Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada.