An umbrella review of the use of platelet-rich plasma in the treatment of androgenetic alopecia
To evaluate the efficacy of platelet-rich plasma (PRP) in the treatment of androgenetic alopecia, as well as establish an effective treatment protocol and optimal PRP preparation procedure.
METHODS:We searched the PubMed, Scopus, Embase, Cochrane, CNKI, and Wanfang databases from inception to October 29, 2021, using PROSPERO's International Prospective Register of Systematic Reviews (registration ID: CRD42022295921).
RESULTS:The original literature search revealed 215 reviews; after duplication removal, 89 papers were eliminated, 95 were eliminated after reading the titles and abstracts, and eventually, 28 articles were included after reading the complete text.
CONCLUSIONS:PRP treatment for androgenetic alopecia is effective, and we recommend the following: (1) a PRP volume of at least 0.05 ml/cm2 , preferably 0.1 ml/cm2 ; (2) at least three consecutive treatments at an interval of 1 month; (3) intensive therapy is beneficial and can be provided from 3 to 6 months after continuous treatment; (4) objective indicators such as hair diameter, hair count; (5) long-term follow-up.
KEYWORDS: | PRP; androgenetic alopecia; efficacy; platelet-rich plasma; umbrella review |
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MESH HEADINGS: | Humans; Systematic Reviews as Topic; Alopecia; Hair; Treatment Outcome; Platelet-Rich Plasma |
Study Design: | Systematic Review |
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Language: | eng |
Credits: | Bibliographic data from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine |