Characterization and Analysis of Chitosan-Gelatin Composite-Based Biomaterial Effectivity as Local Hemostatic Agent: A Systematic Review

Doctoral Program, Faculty of Dentistry, Universitas Padjadjaran, Bandung 45124, Indonesia. Department of Oral and Maxillo Facial Surgery, Faculty of Dentistry, Universitas Padjadjaran, Bandung 45124, Indonesia. Department of Orthodontic, Faculty of Dentistry, Universitas Padjadjaran, Bandung 45124, Indonesia. The Indonesian Naval Dental Institute, Jakarta 10210, Indonesia. Department of Dental Materials Science and Technology, Faculty of Dentistry, Universitas Padjadjaran, Bandung 45124, Indonesia. Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur 50603, Malaysia.

Polymers. 2023;15(3)
Full text from:
Abstract
Chitosan and gelatin were the most widely used natural materials in pharmaceutical and medical fields, especially as local hemostatic agents, independently or as a composite material with the addition of other active substances. Chitosan and gelatin have excellent properties in biocompatibility, biodegradability, non-toxicity and water absorption capacity. The objective of this review was to analyze the characteristics of chitosan-gelatin (CG) composite-based biomaterial and its effectivity as a local hemostatic agent. We used PRISMA guidelines and the PICO framework to compile this review. The findings demonstrated that the CG composite-based biomaterial had excellent physical, chemical, mechanical properties and local hemostatic agent activity by adding other active substances such as oxidized fibers (OF), silica nanoparticles (SiNPs), calcium (Ca) and biphasic calcium phosphate (BCP) or by setting the CG composite proportion ratio.
Study details
Study Design : Systematic Review
Language : eng
Credits : Bibliographic data from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine