Norwich Medical School, University of East Anglia (UEA), Norwich Research Park, Norwich NR4 7TJ, UK. Department of Cardiology, Norfolk and Norwich University Hospital, Colney Lane, Norwich NR4 7UY, UK. Medical School, King's College London, Strand, London WC2R 2LS, UK. Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK. Royal Papworth Hospital, Papworth Rd, Trumpington, Cambridge CB2 0AY, UK.