Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy; Scientific Direction, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milano, Italy; Department of Pathophysiology and Transplantation, Università degli Studi di Milano., Milan, Italy; Pediatrics Department Ain Shams University, Cairo, Egypt; Pediatrics, Cairo University, Cairo, Egypt; Jehangir Clinical Development Centre, Department of Hematology, Jehangir Hospital Premises, Pune, India; Pediatric Congenital Hematologic Disorders Research Center,Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Pathology, J J M Medical College,, Davangere, India; Centre for Blood Disorders, Chennai, India; Shiraz Hematology Research Center, Shiraz, Iran; Lokmanya Tilak Municipal Medical College & General Hospital, Mumbai, India; St. John's Medical College & Hospital, Bangalore, India; Children's Hospital of Los Angeles, Los Angeles, CA; All India Institute of Medical Sciences Department of Haematology, New Delhi, India; Department of Haematology, Sahyadri Speciality Hospital, Pune, India; Kasturba Medical College, Manipal University, Manipal, India; Hospital de Especialidades UMAE, Istituto Mexicano del Seguro Social (IMSS), Monterry, Mexico;