Analysis of antithrombotic medication of traditional Chinese medicine based on data mining and network pharmacology

Chinese Traditional and Herbal Drugs. 2021;52(4):1063-1072
Abstract
Objective: Deep venous thrombosis is an important cause of death and poor prognosis in critically ill patients with COVID-19 This paper excavates the prescription rules of TCM in preventing and treating thrombosis, so as to provide reference for Chinese medicine in preventing and treating deep venous thrombosis in critically ill patients with COVID-19 Methods: Based on the journal literature collected from CNKI and Wan-fang database, excel 2010 and Clementine 12 0 software were used to analyze the association rules of the included standard traditional Chinese medicine, and analyze the enrichment of GO and KEGG in the core drug groups with the method of network pharmacology The mechanism of action was studied and verified by molecular docking Results: A total of 356 antithrombotic prescriptions were screened from CNKI and Wan-fang database, 25 high-frequency herbs were found, and seven high-frequency drug groups were obtained by further correlation analysis Among them, there were 23 effective chemical components in the core drug group "Honghua (Carthami Flos)-Taoren (Persicae Semen)-Chishao (Paeoniae Radix Rubra)-Chuanxiong (Chuanxiong Rhizoma)", 41 intersection targets between core drug group and thrombus PPI network mainly involved key target proteins such as IL6, VEGFA, CASP3, ALB, EGFR, MAPK8, etc Go functional enrichment analysis revealed 971 biological process entries (P < 0 05), and 105 pathways (P < 0 05) were obtained from KEGG enrichment, which mainly involved Kaposi's sarcoma herpes virus infection, human cytomegalovirus infection, fluid shear force, atherosclerosis, hepatitis B and other pathways The results showed that luteolin, quercetin and baicalein were the active components with better binding ability to IL-6 Conclusion: The key active components in the core drug group can play an antithrombotic role by regulating key targets such as IL-6, and by means of the pathways of Kaposi's sarcoma herpesvirus infection, human cytomegalovirus infection, fluid shear force, atherosclerosis, hepatitis B, etc , with view to providing a reference for the prevention and treatment of deep vein thrombosis in critically ill patients with COVID-19
Study details
Credits : Bibliographic data from Global Research on Coronavirus Disease (COVID-19) Database: World Health Organisation, Creative Commons Licence CC BY-NC-SA 3.0 IGO.