Recovery of innate immune cells and persisting alterations in adaptive immunity in the peripheral blood of convalescent plasma donors at eight months post sars-cov-2 infection

Microorganisms. 2021;9(3):1-12
Persisting alterations and unique immune signatures have been previously detected in the peripheral blood of convalescent plasma (CP) donors at approximately two months after initial SARS-CoV-2 infection This article presents the results on the sequential analysis of 47 CP donors at a median time of eight months (range 7 5–8 5 months) post infection, as assessed by flow cytometry Interestingly, our results show a significant variation of the relevant immune subset composition among CP donors Regarding innate immunity, both non-classical monocytes, and CD11b-granulocytes had fully recovered at eight months post COVID-19 infection Intermediate monocytes and natural killer (NK) cells had already been restored at the two-month evaluation and remained stable Regarding adaptive immunity, the COVID-19-related skewed Th1 and Th2 cell polarization remained at the same levels as in two months However, low levels of total B cells were detected even after eight months from infection A persisting reduction of CD8+ Tregs and changes in the NKT cell compartment were also remarkable CP donors present with a unique immune landscape at eight months post COVID-19 infection, which is characterized by the notable restoration of the components of innate immunity along with a persisting imprint of SARS-CoV-2 in cells of the adaptive immunity © 2021 by the authors Licensee MDPI, Basel, Switzerland
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Language : en
Credits : Bibliographic data from Global Research on Coronavirus Disease (COVID-19) Database: World Health Organisation, Creative Commons Licence CC BY-NC-SA 3.0 IGO.