Patients with suspected transfusion-transmitted infections (29 studies, n= 74).
Systematic review of the published cases of arbovirus transmission through the transfusion of blood or blood components.
A total of 74 cases of transfusion-transmitted infections were identified from 10 arboviruses: West Nile virus (n= 42), dengue virus (n= 18), Zika virus (n= 3), yellow fever vaccine virus (n= 3), tick-borne encephalitis virus (n= 2), Japanese encephalitis virus (n= 2), Powassan virus (n= 1), St. Louis encephalitis virus (n= 1), Ross River virus (n= 1) and Colorado tick fever virus (n= 1). The blood component most commonly involved was red blood cells (n= 35, 47.3%; 95% confidence interval [CI]: 35.9% to 58.7%). In 54.1% (n= 40; 95% CI: 42.7%-65.47%) of the cases, the recipient was immunosuppressed. Transmission resulted in death in 18.9% (n= 14; 95% CI: 10.0%-27.8%) of the recipients. In addition, 18 additional arboviruses were identified with a potential threat to transfusion safety.