Women with primary postpartum haemorrhage (PPH) after vaginal delivery (2 studies, n= 14,363).
Tranexamic acid (TXA), (n= 7,165).
Placebo or no treatment (n= 7,198).
Women who received TXA soon after the diagnosis of PPH had a significantly lower incidence of hysterectomy (0.5% vs 0.8%; RR 0.63, 95% CI 0.42-0.94), compared to those who did not. The risk of thrombotic events was not increased in the TXA group.