Haemostasis and analgesia with autologous platelet-rich plasma in tonsillectomy
The Journal of laryngology and otology. 2019;:1-7
OBJECTIVE A single-centre, single-blinded prospective experimental study was conducted to determine the effectiveness of autologous platelet-rich plasma applied to the tonsillar bed post-operatively in reducing post-operative pain and haemorrhage. METHODS Platelet-rich plasma, prepared prior to surgery, was applied with calcium gluconate to one randomly chosen tonsillar fossa. Pain and haemorrhage were analysed, using a visual analogue scale and a pre-defined grading scale respectively, four times on the day of surgery at 2-hourly intervals, and thrice on the following day. RESULTS The pain score and haemorrhage grade on the test side were lower than on the control side. These findings were statistically significant. CONCLUSION This pilot study, conducted in India, revealed valid positive results for a promising new technology. The manual preparation of platelet-rich plasma could be automated in the future to allow a larger sample size.
Platelet-rich plasma for pediatric tonsillectomy patients
The Laryngoscope. 2008;118((10):):1765-7.
OBJECTIVES/HYPOTHESIS To determine if placement of autologous platelet-rich plasma (PRP) on the tonsil beds at the time of tonsillectomy would decrease postoperative pain and complications. STUDY DESIGN Double blind, randomized, prospective study. METHODS Seventy children were recruited to participate in the study, ranging in age from 4 to 15 years. They were randomized to treatment (PRP) or control groups. The parents, patients, and nurses were blinded as to which group they were in. Postoperative pain scores were obtained using the FACES pain scale and recorded in a home diary. RESULTS Seventy patients were recruited to the study, and 12 did not submit their diaries and were considered to drop out of the study. Demographic data were similar for both control and treatment groups. Median pain scores, medication use, days to normal diet, and office visits did not differ between the two groups. CONCLUSIONS PRP applied once at the time of tonsillectomy does not improve postoperative pain or recovery in pediatric patients.