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The efficacy of combined use of intraarticular and intravenous tranexamic acid on reducing blood loss and transfusion rate in total knee arthroplasty
Lin SY, Chen CH, Fu YC, Huang PJ, Chang JK, Huang HT
Journal of Arthroplasty. 2015;30((5)):776-80.
Abstract
The purpose of this study is to investigate the effect of preoperative intravenous (IV) and intraoperative topical administration of tranexamic acid (TXA) in total knee arthroplasty (TKA). A total of 120 patients were and randomly allocated to either topical group, combined group, or control group. The mean total blood loss was lower in the combined and topical groups (705mL and 579mL, respectively) in comparison with control group (949mL, P<0.001). There was a significant difference in transfusion rate among groups (P=0.009). The postoperative hemoglobin drop and total drain amount were significantly less in the combined group compared to other groups. In conclusion, combining preoperative IV injection and topical administration of TXA can effectively reduce blood loss and transfusion rate. Copyright © 2014 Elsevier Inc. All rights reserved.