0
selected
-
1.
Association between leukoreduced red blood cell transfusions and hospital-acquired infections in critically ill children: A secondary analysis of the TRIPICU study
Flatman LK, Fergusson DA, Lacroix J, Ducruet T, Papenburg J, Fontela PS
Vox sanguinis. 2021
Abstract
BACKGROUND AND OBJECTIVES Hospital-acquired infections (HAIs) are an important problem in critically ill children. Studies show associations between the transfusion of non-leukoreduced red blood cell units (RBC) and increased HAI incidence rates (IRs). We hypothesize that transfusing pre-storage leukoreduced RBC is also associated with increased HAI IR. We aim to evaluate the associations between (1) a leukoreduced RBC restrictive transfusion strategy and HAI IR, (2) leukoreduced RBC transfusions and HAI IR, and (3) the number or volume of leukoreduced RBC transfusions and HAI IR in critically ill children. MATERIALS AND METHODS This post hoc secondary analysis of the "Transfusion Requirement in Paediatric Intensive Care Units" (TRIPICU) randomized controlled trial (637 patients) used quasi-Poisson multivariable regression models to estimate HAI incidence rate ratios (IRRs) and 95% confidence intervals (CI). RESULTS A restrictive transfusion strategy yielded an IRR of 0.88 (95% CI 0.67, 1.16). The association between transfusing leukoreduced RBCs (IRR 1.25; 95% CI 0.73, 2.13) and HAI IR was not statistically significant. However, we observed significant associations between patients who received >20 cc/kg volume of leukoreduced RBC transfusions (IRR 2.14; 95% CI 1.15, 3.99) and ≥3 leukoreduced RBC transfusions (IRR 2.40; 95% CI 1.15, 4.99) and HAI IR. CONCLUSION Exposing critically ill children to >20 cc/kg or ≥3 leukoreduced RBC transfusions were associated with higher HAI IR, suggesting dose-response patterns.
-
2.
Red blood cell transfusion thresholds in pediatric patients with sepsis
Karam O, Tucci M, Ducruet T, Hume HA, Lacroix J, Gauvin F
Pediatric Critical Care Medicine. 2011;12((5):):512-8.
Abstract
OBJECTIVES In children with severe sepsis or septic shock, the optimal red blood cell transfusion threshold is unknown. We analyzed the subgroup of patients with sepsis and transfusion requirements in a pediatric intensive care unit study to determine the impact of a restrictive vs. liberal transfusion strategy on clinical outcome. DESIGN Subgroup analysis of a prospective, multicenter, randomized, controlled trial. SETTING Multicenter pediatric critical care units. PATIENTS Stabilized critically ill children (mean systemic arterial pressure >2 sd below normal mean for age and cardiovascular support not increased for at least 2 hrs before enrollment) with a hemoglobin <= 9.5 g/dL within 7 days after pediatric critical care unit admission. INTERVENTIONS One hundred thirty-seven stabilized critically ill children with sepsis were randomized to receive red blood cell transfusion if their hemoglobin decreased to either <7.0 g/dL (restrictive group) or 9.5 g/dL (liberal group). MEASUREMENTS AND MAIN RESULTS In the restrictive group (69 patients), 30 patients did not receive any red blood cell transfusion, whereas only one patient in the liberal group (68 patients) never underwent transfusion (p < .01). No clinically significant differences were found for the occurrence of new or progressive multiple organ dysfunction syndrome (18.8% vs. 19.1%; p = .97), for pediatric critical care unit length of stay (p = .74), or for pediatric critical care unit mortality (p = .44) in the restrictive vs. liberal group. CONCLUSIONS In this subgroup analysis of children with stable sepsis, we found no evidence that a restrictive red cell transfusion strategy, as compared to a liberal one, increased the rate of new or progressive multiple organ dysfunction syndromes. Furthermore, a restrictive transfusion threshold significantly reduced exposure to blood products. Our data suggest that a hemoglobin level of 7.0 g/dL may be safe stabilized for children with sepsis, but further studies are required to support this recommendation.
-
3.
Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients
Gauvin F, Spinella PC, Lacroix J, Choker G, Ducruet T, Karam O, Hébert PC, Hutchison JS, Hume HA, Tucci M, et al
Transfusion. 2010;50((9):):1902-13.
Abstract
BACKGROUND The objective was to determine if there is an association between red blood cell (RBC) storage time and development of new or progressive multiple organ dysfunction syndrome (MODS) in critically ill children. STUDY DESIGN AND METHODS This was an analytic cohort analysis of patients enrolled in a randomized controlled trial, TRIPICU (Transfusion Requirements in Pediatric Intensive Care Units; ISRCTN37246456), in which stable critically ill children were randomly assigned to a restrictive or liberal strategy. Transfused patients were analyzed using three different sliding time cutoffs (7, 14, and 21 days). Storage time for multiply transfused patients was defined according to the oldest unit transfused. RESULTS A total of 455 patients were retained (liberal, 310; restrictive, 145). Multivariate logistic regression was performed to determine independent associations. In the restrictive group, a maximum RBC storage time of more than 21 days was independently associated with new or progressive MODS (adjusted odds ratio [OR], 3. 29; 95% confidence interval [CI], 1. 21-9. 04). The same association was found in the liberal group for a storage time of more than 14 days (adjusted OR, 2. 50; 95% CI, 1. 12-5. 58). When the two groups were combined in a meta-analysis, a storage time of more than 14 days was independently associated with increased MODS (adjusted OR, 2. 23; 95% CI, 1. 20-4. 15) and more than 21 days was associated with increased Pediatric Logistic Organ Dysfunction (PELOD) scores (adjusted mean difference, 4. 26; 95% CI, 1. 99-6. 53) and higher mortality (9. 2% vs. 3. 8%). CONCLUSION Stable critically ill children who receive RBC units with storage times longer than 2 to 3 weeks may be at greater risk of developing new or progressive MODS.
-
4.
Association between length of red blood cell storage and multiple organ dysfunction syndrome in pediatric intensive care
Tucci M, Willems A, Toledano BJ, Hume H, Lacroix J, HÚbert P, Ducruet T, Choker G
Transfusion. 2008;48((S2):):254A.. Abstract No. S126-040D.
-
5.
Transfusion threshold in post-surgical pediatric intensive care patients
Rouette J, Trottier H, Ducruet T, Beaunoyer M, Lacroix J, Tucci M
Transfusion. 2008;48((S2):):254A.. Abstract No. S128-040D.
-
6.
Transfusion strategies for patients in pediatric intensive care units
Lacroix J, Hébert PC, Hutchison JS, Hume HA, Tucci M, Ducruet T, Gauvin F, Collet JP, Toledano BJ, Robillard P, et al
The New England Journal of Medicine. 2007;356((16):):1609-19.
Abstract
BACKGROUND The optimal hemoglobin threshold for erythrocyte transfusions in critically ill children is unknown. We hypothesized that a restrictive transfusion strategy of using packed red cells that were leukocyte-reduced before storage would be as safe as a liberal transfusion strategy, as judged by the outcome of multiple-organ dysfunction. METHODS In this noninferiority trial, we enrolled 637 stable, critically ill children who had hemoglobin concentrations below 9. 5 g per deciliter within 7 days after admission to an intensive care unit. We randomly assigned 320 patients to a hemoglobin threshold of 7 g per deciliter for red-cell transfusion (restrictive-strategy group) and 317 patients to a threshold of 9. 5 g per deciliter (liberal-strategy group). RESULTS Hemoglobin concentrations were maintained at a mean (+/-SD) level that was 2. 1+/-0. 2 g per deciliter lower in the restrictive-strategy group than in the liberal-strategy group (lowest average levels, 8. 7+/-0. 4 and 10. 8+/-0. 5 g per deciliter, respectively; P<0. 001). Patients in the restrictive-strategy group received 44% fewer transfusions; 174 patients (54%) in that group did not receive any transfusions, as compared with 7 patients (2%) in the liberal-strategy group (P<0. 001). New or progressive multiple-organ dysfunction syndrome (the primary outcome) developed in 38 patients in the restrictive-strategy group, as compared with 39 in the liberal-strategy group (12% in both groups) (absolute risk reduction with the restrictive strategy, 0. 4%; 95% confidence interval, -4. 6 to 5. 4). There were 14 deaths in each group within 28 days after randomization. No significant differences were found in other outcomes, including adverse events. CONCLUSIONS In stable, critically ill children a hemoglobin threshold of 7 g per deciliter for red-cell transfusion can decrease transfusion requirements without increasing adverse outcomes. (Controlled-trials. com number, ISRCTN37246456 [controlled-trials. com]. ).
-
7.
Transfusion requirements in pediatric intensive care units a multicenter randomized controlled clinical trial
Lacroix J, Hebert PC, Collet J, Ducruet T, Gauvin F, Hume HA, Hutchison JS, Toleano B, Tucci M
Transfusion. 2006;46((9s):):2A.. Abstract No. P4-030A.