Population
People with idiopathic thrombocytopenia purpura (ITP) enrolled in clinical trials, and identified by systematic review (n= 2,615, 19 RCTs).
Intervention
Interventions for ITP: romiplostim, eltrombopag, rituximab, prednisolone, IVIG, efgartimod, dexamethasone or avatrombopag.
Comparison
Placebo, dexamethasone, danazol or other drug interventions.
Outcome
The efficacy of eltrombopag plus rituximab, avatrombopag, dexamethasone plus anti-HP, and dexamethasone plus rhTPO was significantly higher than placebo (odds ratio [OR]: 46.66, 29.44, 2.66, 1.86) or dexamethasone alone (OR: 46.22, 29.01, 2.22, 1.40). Placebo, oral immunosuppressants, and dexamethasone plus oseltamivir were less effective than the other ITP therapies tested.