Population
Patients with chronic kidney disease-induced anaemia (9 studies).
Intervention
Roxadustat.
Comparison
Erythropoiesis-stimulating agents (ESAs) or erythropoietin analogues or placebo.
Outcome
In the non-dialysis-dependent (NDD) high-dose/low-dose subgroups, the change in haemoglobin (Hb) levels was significantly higher in the roxadustat group than in the placebo group. The Hb response rate of the roxadustat is higher in the NDD subgroup than in the placebo group (MD=6.92). In the dialysis-dependent subgroup, there was no significant difference in the change in Hb levels or the Hb response rate between the roxadustat and ESA groups. There was no change in the mortality in the roxadustat group compared to that in the placebo/ESA group.