Population
Patients with severe COVID-19 disease (6 studies, n= 382).
Intervention
Therapeutic plasma exchange (TPE).
Comparison
Standard treatment.
Outcome
The random model analysis for mortality evaluated a risk ratio of 0.38 (95% CI: 0.28-0.52) with a significant reduction in the TPE group. The certainty of the evidence was moderate, with a risk ratio of 0.34 (95% CI: 0.24-0.49). Length of intensive care unit stays between TPE versus standard care showed a standardized mean difference of 0.08 (95% CI: -0.38-0.55) and was not significant.