Population
Patients attended by Helicopter Emergency Medical Service (HEMS) paramedics with suspected critical bleeding after trauma (n= 20).
Intervention
Two units of freeze-dried plasma (Lyoplas N-w), (n= 9).
Comparison
Standard care (no plasma), (n= 11).
Outcome
The primary outcome was the proportion of eligible patients enrolled and provided the intervention. Secondary outcomes included preliminary data on effectiveness, including mortality censored at 24 hours and at hospital discharge, and adverse events. Nineteen patients (76%) received the allocated intervention. Median time from randomization to hospital arrival was 92.5 mins (IQR 68-101.5). Mortality may have been lower in the freeze-dried plasma group at 24h (RR 0.24; 95% CI [0.03, 1.73]) and at hospital discharge (RR 0.73; 95% CI [0.24, 2.27]. No serious adverse events related to the trial interventions were reported.