1.
Evaluation of two secondary prophylaxis regimens of recombinant factor IX (r-IX) in moderately severe to severe (FIX <=2%) hemophilia B patients
Rendo P, Barrette-Grischow M-K, Smith L, Korth-Bradley JM, Charnigo R, Shafer FE
Blood. 2012;120((21):): Abstract No. 4628.
2.
Single dose of anti-D immune globulin at 75 microg/kg is as effective as intravenous immune globulin at rapidly raising the platelet count in newly diagnosed immune thrombocytopenic purpura in children
Tarantino MD, Young G, Bertolone SJ, Kalinyak KA, Shafer FE, Kulkarni R, Weber LC, Davis ML, Lynn H, Nugent DJ, et al
The Journal of Pediatrics. 2006;148((4):):489-94.
Abstract
OBJECTIVE To conduct a randomized prospective trial of immune globulin treatment for 105 Rh+ children with newly-diagnosed immune thrombocytopenic purpura and a platelet count<20,000/microL, to determine whether anti-D immune globulin (anti-D) is as effective as intravenous immune globulin (IVIg). STUDY DESIGN Eligible patients received either a single intravenous dose of 50 microg/kg anti-D (anti-D50), 75 microg/kg anti-D, (anti-D75), or 0. 8 g/kg IVIg, (IVIg). Patients were monitored for response to treatment and adverse events. RESULTS By 24 hours after treatment 50%, 72%, and 77% of patients in the anti-D50, anti-D75, and IVIg groups, respectively, had achieved a platelet count>20,000/microL (P=. 03). By day 7, hemoglobin concentrations decreased by 1. 6 g/dL, 2 g/dL, and 0. 3 g/dL in the anti-D50, anti-D75, and IVIg groups, respectively. Headache, fever, or chills occurred least often in the anti-D50 group. CONCLUSIONS A single 75 microg/kg dose of Anti-D raised the platelet count in children with newly diagnosed immune thrombocytopenic purpura more rapidly than standard-dose anti-D and as effectively as IVIg, with an acceptable safety profile.
3.
High-dose anti-D immune globulin raises the platelet count in newly diagnosed childhood ITP more rapidly than standard-dose anti-D and higher than IVIg
Tarantino MD, Young G, Bertolone SJ, Kalinyak K, Shafer FE, Kulkarni R, Weber L, Nugent D
Pediatric Research. 2003;: Abstract No. LB3-15.
4.
High-dose anti-D immune globulin is as effective as IVIg in the treatment of newly diagnosed immune thrombocytopenic purpura (ITP) in children
Tarantino MD, Young G, Bertolone SJ, Shafer FE, Kulkarni R, Kalinyak K,, et al.,
Blood. 2003;102((11, Pt 2):):299a-300a.. Abstract No. 1072.