1.
Evaluation of two secondary prophylaxis regimens of recombinant factor IX (r-IX) in moderately severe to severe (FIX <=2%) hemophilia B patients
Rendo P, Barrette-Grischow M-K, Smith L, Korth-Bradley JM, Charnigo R, Shafer FE
Blood. 2012;120((21):): Abstract No. 4628.
2.
A multicenter, open-label study to compare on-demand treatment with two prophylaxis regimens of recombinant coagulation factor IX in subjects with hemophilia B
Valentino LA, Plushch O, Rusen L, Andreeva T, Elezovic I, Charnigo R, Baumann J, Kollmler C, Smith L, Rendo P
Journal of Thrombosis and Haemostasis. 2011;9((Suppl 2):):357. Abstract No. P-TU-155.
3.
A prospective randomized, controlled trial of intravenous versus oral iron for moderate iron deficiency anaemia of pregnancy
Khalafallah A, Dennis A, Bates J, Bates G, Robertson IK, Smith L, Ball MJ, Seaton D, Brain T, Rasko JE
Journal of Internal Medicine. 2010;268((3):):286-95.
Abstract
BACKGROUND Iron deficiency anaemia is the most common deficiency disorder in the world, affecting more than one billion people, with pregnant women at particular risk. OBJECTIVES AND DESIGN We conducted a single site, prospective, nonblinded randomized-controlled trial to compare the efficacy, safety, tolerability and compliance of standard oral daily iron versus intravenous iron. SUBJECTS We prospectively screened 2654 pregnant women between March 2007 and January 2009 with a full blood count and iron studies, of which 461 (18%) had moderate IDA. Two hundred women matched for haemoglobin concentration and serum ferritin level were recruited. INTERVENTIONS Patients were randomized to daily oral ferrous sulphate 250 mg (elemental iron 80 mg) with or without a single intravenous iron polymaltose infusion. RESULTS Prior to delivery, the intravenous plus oral iron arm was superior to the oral iron only arm as measured by the increase in haemoglobin level (mean of 19. 5 g/L vs. 12 g/L; P < 0. 001); the increase in mean serum ferritin level (222 microg/L vs. 18 ug/L; P < 0. 001); and the percentage of mothers with ferritin levels below 30 microg/L (4. 5% vs. 79%; P < 0. 001). A single dose of intravenous iron polymaltose was well tolerated without significant side effects. CONCLUSIONS Our data indicate that intravenous iron polymaltose is safe and leads to improved efficacy and iron stores compared to oral iron alone in pregnancy-related IDA.
4.
A prospective randomised-controlled trial evaluating the effect of intravenous versus oral iron on haemoglobin and ferritin levels in the management of iron deficiency anaemia during pregnancy
Khalafallah A, Dennis A, Bates J, Bates G, Robertson I, Smith L, Ball M, Seaton D, Brain T
HSANZ Meeting. 2009;:A351.. Abstract No. P119.
5.
Compliance and tolerability of iron therapy during pregnancy
Khalafallah A, Bates G, Dennis A, Bates J, Smith L, Shaw S, Bertram J, Beamish M, Rooney K
HSANZ Meeting. 2008;:A200.. Abstract No. O105.
6.
A prospective randomised trial of intravenous iron therapy versus oral iron for iron deficiency anaemia in pregnant women
Khalafallah A, Dennis A, Bates G, Bates J, Shaw S, Smith L, Bertram J, Seaton D, Brain T, Beamish M, et al
HSANZ Meeting. 2008;:A199.. Abstract No. O104.
7.
A prospective randomised trial of intravenous iron therapy versus oral iron for iron deficiency anaemia in pregnant Australian women
Khalafallah AA, Dennis A, Bates J, Bates G, Smith L, Shaw S, Seaton D, Berteram J, Robertson I, Ball M, et al
Blood. 2007;110((11):): Abstract No. 3750.
8.
Prospective double-blind study of small volume neonatal transfusion with RBCs up to 35 days old
Eshleman JR, Akinbi H, Pleasure J, Asakura T, Magee D, Smith L, Jefferies L
Transfusion. 1994;34((10S):):32S.. Abstract No. S126.