Adult acute myeloid leukemia patients (11 studies, n= 1,407).
Leukapheresis intervention (n= 1,090).
Not receiving leukapheresis (n= 317).
Pooled analysis showed that there was no significant difference in early mortality between patients receiving leukapheresis and not receiving leukapheresis in studies using hyperleukocytosis cutoff of 95,000/mm3 or 100,000/mm3. Studies using hyperleukocytosis cutoff of 50,000/mm3 showed no benefits of early mortality.